CAD Model to Physical Part - Problems faced

CAD Show and tell
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There are many Engineers, Makers, Product Designers on 3D Hubs and I want to understand your pain points.

If your are a Mechanical Engineer or a Product Designer, what are the problems you face going from CAD Model to a physical part? I am interested in anything from manufacturing issues with the design to generating BOM (Bill of Materials) to time wasted while waiting for RFQ (Request for Quote) from suppliers.

How do you currently address the problems you face?

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Let me start: One of the common complain I am aware of is Engineers pending days sending out RFQs, waiting for feedback, sending drawings, asking for different quantities, waiting for more feedback, only to receive back less than optimal pricing and lead times. Another problem is that designers are not always fully aware of the capabilities and limitations of the latest manufacturing technology advances.

What are your struggles?